1. The future of basic science in orthopaedics and traumatology
14 jun 2021 · The future of basic science in orthopaedics and traumatology can only be managed by an even more intensified exchange between basic scientists and clinicians.
Orthopaedic and trauma research is a gateway to better health and mobility, reflecting the ever-increasing and complex burden of musculoskeletal diseases and injuries in Germany, Europe and worldwide. Basic science in orthopaedics and traumatology addresses the complete organism down to the molecule among an entire life of musculoskeletal mobility. Reflecting the complex and intertwined underlying mechanisms, cooperative research in this field has discovered important mechanisms on the molecular, cellular and organ levels, which subsequently led to innovative diagnostic and therapeutic strategies that reduced individual suffering as well as the burden on the society. However, research efforts are considerably threatened by economical pressures on clinicians and scientists, growing obstacles for urgently needed translational animal research, and insufficient funding. Although sophisticated science is feasible and realized in ever more individual research groups, a main goal of the multidisciplinary members of the Basic Science Section of the German Society for Orthopaedics and Trauma Surgery is to generate overarching structures and networks to answer to the growing clinical needs. The future of basic science in orthopaedics and traumatology can only be managed by an even more intensified exchange between basic scientists and clinicians while fuelling enthusiasm of talented junior scientists and clinicians. Prioritized future projects will master a broad range of opportunities...
2. Is Drp1 a link between mitochondrial dysfunction and inflammation in ...
We describe the recent data that demonstrate the link between altered mitochondrial dysfunction and the inflammatory cascade.
Recent advances highlight that inflammation is critical to Alzheimer Disease (AD) pathogenesis. Indeed, several diseases characterized by inflammation are considered risk factors for AD, such as type 2 diabetes, obesity, hypertension, and traumatic ...
3. Nature embodied in time and space, in Kontext/Kontinuum. „Ökologische ...
Insights of ecological psychology and neuroscience are used in their relevance for the „contextualization“ (embeddedness) of the body and the „temporalization“ ...
Europäische Akademie für bio-psycho-soziale Gesundheit / Fritz-Perls-Institut
4. Spinal Cord Organoids to Study Motor Neuron Development and Disease
In this review, we outline the evolution of human PSC-derived models for generating spMN and recapitulating SpC development.
Motor neuron diseases (MNDs) are a heterogeneous group of disorders that affect the cranial and/or spinal motor neurons (spMNs), spinal sensory neurons and the muscular system. Although they have been investigated for decades, we still lack a comprehensive understanding of the underlying molecular mechanisms; and therefore, efficacious therapies are scarce. Model organisms and relatively simple two-dimensional cell culture systems have been instrumental in our current knowledge of neuromuscular disease pathology; however, in the recent years, human 3D in vitro models have transformed the disease-modeling landscape. While cerebral organoids have been pursued the most, interest in spinal cord organoids (SCOs) is now also increasing. Pluripotent stem cell (PSC)-based protocols to generate SpC-like structures, sometimes including the adjacent mesoderm and derived skeletal muscle, are constantly being refined and applied to study early human neuromuscular development and disease. In this review, we outline the evolution of human PSC-derived models for generating spMN and recapitulating SpC development. We also discuss how these models have been applied to exploring the basis of human neurodevelopmental and neurodegenerative diseases. Finally, we provide an overview of the main challenges to overcome in order to generate more physiologically relevant human SpC models and propose some exciting new perspectives.
5. publication_list - MPI-IE - Max-Planck-Gesellschaft
: Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease. Cell Metabolism 33, pp. 2260 - 2276 ( ...
Journal Article
6. [PDF] 2021 IEEE International Conference on Bioinformatics and Biomedicine ...
12 dec 2021 · BEA-SEGNET: BODY AND EDGE AWARE NETWORK FOR MEDICAL IMAGE ... Xinlu Zhang, Shiyang Li, Zhuowei Cheng, Rachael Callcut, Linda Petzold. A ...
7. The choroid plexus: a missing link in our understanding of brain ...
... body-fluid such as the cerebrospinal liquid.” It is a daunting task to ... Anton ES, Edwards D, Garcez P, Hoerder-Suabedissen A, Kriegstein A. New ...
Keywords: blood-brain barrier, cerebrospinal fluid, choroid plexus, development, drug penetration
8. Great Freedom - Reviews - Reverse Shot
4 mrt 2022 · ... body conveying its own poetic feeling. Rogowski wields his ... Cannes 2021 Dispatch: From the Darkness By Jordan Cronk | July 14, 2021 ...
Great Freedom confirms Rogowski as a protean and exceptionally physical performer, a screen star who appears to emit his own force field.
9. 1.26.2 - nginx
*) Bugfix: in request body filters internal API when using HTTP/2 and buffering of the data being processed. Changes with nginx 1.21.2 31 Aug 2021 *) Change: ...
Changes with nginx 1.26.2 14 Aug 2024 *) Security: processing of a specially crafted mp4 file by the ngx_http_mp4_module might cause a worker process crash (CVE-2024-7347). Thanks to Nils Bars. Changes with nginx 1.26.1 29 May 2024 *) Security: when using HTTP/3, processing of a specially crafted QUIC session might cause a worker process crash, worker process memory disclosure on systems with MTU larger than 4096 bytes, or might have potential other impact (CVE-2024-32760, CVE-2024-31079, CVE-2024-35200, CVE-2024-34161). Thanks to Nils Bars of CISPA. *) Bugfix: reduced memory consumption for long-lived requests if "gzip", "gunzip", "ssi", "sub_filter", or "grpc_pass" directives are used. *) Bugfix: nginx could not be built by gcc 14 if the --with-libatomic option was used. Thanks to Edgar Bonet. *) Bugfix: in HTTP/3. Changes with nginx 1.26.0 23 Apr 2024 *) 1.26.x stable branch. Changes with nginx 1.25.5 16 Apr 2024 *) Feature: virtual servers in the stream module. *) Feature: the ngx_stream_pass_module. *) Feature: the "deferred", "accept_filter", and "setfib" parameters of the "listen" directive in the stream module. *) Feature: cache line size detection for some architectures....
10. Large Language Models in Healthcare and Medical Domain
8 jul 2024 · ... body of medical knowledge, decipher intricate patient records, and ... [16] Fabio Petroni, Tim Rocktäschel, Patrick Lewis, Anton Bakhtin, Yuxiang ...
Zabir Al Nazi University of California, Riverside Riverside, CA znazi002@ucr.edu \AndWei Peng Stanford University Palo Alto, CA wepeng@stanford.edu
11. Fresh from Theaters - The Criterion Channel
Our Body. Movie. Our Father, the Devil. Movie ... Movie + 2 extras. Directed by Christian Petzold • 2023 • Germany Starring ...
Look no further than the Criterion Channel for the best contemporary cinema from around the world.
